Abstract
Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian sirtuins family, including SIRT1~7, is involved in many biological processes such as cell survival, proliferation, senescence, stress response, genome stability and metabolism. Evidence accumulated over the past two decades has indicated that sirtuins not only serve as important energy status sensors but also protect cells against metabolic stresses. In this review, we summarize the background of glucose and lipid metabolism concerning sirtuins and discuss the functions of sirtuins in glucose and lipid metabolism. We also seek to highlight the biological roles of certain sirtuins members in cancer metabolism.
Highlights
Metabolism plays an important role in every aspect of a cell
We summarize the evidence to date and try to present a general overview of sirtuins in metabolism regulation from our current knowledge
These changes will promote sirtuins interacting with certain transcriptional factors or cofactors, resulting in changes in transcriptional level of target genes associated with metabolism
Summary
Metabolism plays an important role in every aspect of a cell. When it comes to energy homeostasis, glucose and lipid metabolism are of great importance.
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