Abstract
Sirtuins are a class of enzymes known as nicotinamide adenine dinucleotide (NAD)‐dependent deacetylases. Sirtuins regulate aging, transcription, and metabolism, and are important targets for treating several human diseases. There are seven sirtuins in humans, SIRT1‐7. Four of them (SIRT4‐7) have very weak deacetylase activity, which have caused many confusions and debates in the biological community. My laboratory has recently discovered several novel enzymatic activities, such as desuccinylation and defatty‐acylation, for several sirtuins with no robust deacetylase activity. This have led to the identification of previously unknown protein posttranslational modifications and revealed new biological functions of sirtuins, such as the regulation of protein secretion.
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