Abstract
Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell migration. There are seven sirtuins in humans, SIRT1-7, each with unique enzymatic activities, regulatory mechanisms, subcellular localizations, and substrate scopes. They have been indicated in many human diseases, including cancer, neurodegeneration, microbial infection, metabolic and autoimmune diseases. Consequently, interests in development of sirtuin modulators have increased in the past decade. In this brief review, we specifically summarize genetic and pharmacological modulations of sirtuins in cancer, neurological, and cardiovascular diseases. We further anticipate this review will be helpful for scrutinizing the significance of sirtuins in the studied diseases.
Highlights
Sirtuins, the class III histone deacetylase, use NAD+ to remove various acyl modifications on protein lysine residues (Sauve et al, 2001; Sauve et al, 2006; Feldman et al, 2012)
Because this review summarizes modulators that directly bind to sirtuins, we will not explain these indirect modulators in detail
We have summarized the effects of various sirtuin modulators in cancer, neurological, and cardiovascular diseases
Summary
The class III histone deacetylase, use NAD+ to remove various acyl modifications on protein lysine residues (Sauve et al, 2001; Sauve et al, 2006; Feldman et al, 2012). 2′-hydroxyl group and releases the deacylated lysine product and 2′-O-acyl ADP-ribose (Avalos et al, 2005; Feldman et al, 2015; Wang and Lin, 2021). This way, this review can serve as an initial useful guideline for those thinking of using sirtuin modulators in their studies. Inhibiting CD38, which converts NAD+ to various products, with apigenin
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
