Abstract
Background Sirtuin 6 (SIRT6), a NAD+-dependent deacetylase SIRT6 has been demonstrated to inhibit tumor development in a variety of cancers. Colorectal carcinoma is a difficult malignancy with high morbidity and mortality rates. However, it is unknown if SIRT6 has a direct role in colon carcinogenesis or what the underlying mechanism is. Aim and objectives The aim of this work was to study the expression of SIRT6 in colorectal carcinoma and its correlation with other pathological prognostic factors to clarify the role of SIRT6 in colorectal cancer (CRC) and determine whether SIRT6 could be a potential new prognostic biomarker for patients with CRC. Patients and methods We studied the tissues of 40 CRC patients to see whether SIRT6 has a role in colon cancer. Tumor tissue sections have been stained with hematoxylin and eosin and immunostained for SIRT6. Results The clinicopathological features of all cases were studied and statistical correlations between SIRT6 expression and clinicopathological parameters were done showing significant relations between SIRT6 expression and both tumor size and distant metastases with P values equal to 0.042 and 0.016, respectively. Conclusion SIRT6 is thought to play a significant role in the tumorogenesis of cancer colon; larger studies of all cancer colon variants are recommended for further declaration of each role.
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