Sirtuin-1 in Egyptian patients with coronary artery disease

Al-Shabrawy M Abdelnabi,Reham M Ali,Samia Hussein,Alhoussein Alsayed Abdelaal,Imam M Esmayel

doi:10.1186/s43088-021-00164-1

Al-Shabrawy M Abdelnabi, Reham M Ali + Show 3 more

Open Access

https://doi.org/10.1186/s43088-021-00164-1

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Abstract

BackgroundCoronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors.ResultsPlasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels.ConclusionsThe plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation.

Highlights

Coronary artery disease (CAD) represents the leading cause of death worldwide
3 Results There was no significant difference in age, sex, hemoglobin, random blood glucose (RBG), or serum creatinine levels between the study groups (p = 0.081, 0.45, 0.74, 0.477and 0.054 respectively)
Regarding the receiver operating characteristics (ROC) curve, the plasma cutoff level of silent information regulator 1 (SIRT1) in CAD patients was 65.0% accurate in predicting CAD with a significant area under the curve (p = 0.013) at a cutoff value of less than 2.4 ng/mL with a sensitivity of 75.0%, specificity of 55.0%, positive predictive value (PPV) of 62.5%, and negative predictive value (NPV) of 68.7% (Tables 4, 5, Fig. 1)

Summary

Introduction

Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Coronary artery disease (CAD) involves chronic coronary syndrome (CCS) and acute coronary syndrome (ACS). ACS includes unstable angina (UA) and acute myocardial infarction (AMI). Most cases of ACS arise from the disruption of a previously non-severe lesion (an atherosclerotic lesion that was previously hemodynamically insignificant yet vulnerable to rupture). The physical crack of the atherosclerotic plaque that develops in patients with ACS represents practically almost all cases of acute coronary thrombi [2]

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