Abstract
REVIEW article Front. Cell Dev. Biol., 20 January 2015Sec. Cellular Biochemistry Volume 3 - 2015 | https://doi.org/10.3389/fcell.2015.00001
Highlights
Edited by: Cesare Indiveri, University of Calabria, Italy Reviewed by: Eleni Douni, Agricultural University of Athens, Greece
A particular interesting set of recent papers (Shin et al, 2013; Ryu et al, 2014; Yoshizawa et al, 2014) reported findings on the role of SIRT7 in metabolic regulation, the regulation of lipid and energy metabolism in the liver. These papers together clearly suggest a vital role for SIRT7 in hepatic lipid metabolism, which is in line with earlier data showing that the liver has the highest levels of Sirt7 transcripts among adult mice tissues (Ford et al, 2006)
They observed that these Sirt7 KO mice were resistant to high fat diet (HFD)-induced liver steatosis, obesity and glucose intolerance, and showed significantly lower hepatic triglyceride (TG) content compared to wild type
Summary
Edited by: Cesare Indiveri, University of Calabria, Italy Reviewed by: Eleni Douni, Agricultural University of Athens, Greece. These papers together clearly suggest a vital role for SIRT7 in hepatic lipid metabolism, which is in line with earlier data showing that the liver has the highest levels of Sirt7 transcripts among adult mice tissues (Ford et al, 2006).
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