Abstract
INTRODUCTION: Sirolimus (rapamycin) is a macrocyclic triene antibiotic produced by the actinomycete Streptomyces hygroscopicus. It has potent immunosuppressant properties, which works independent of the calcineurin pathways. It does not induce renal insufficiency and is generally used to prevent progression of renal insufficiency. Its use has been associated with infrequent cases of interstitial pneumonitis. We report a case of diffuse alveolar hemorrhage associated with its use.
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