Abstract
Organic and Medicinal chemistry international Journal is an open access journal that is committed to publish the papers on various topics of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties
Highlights
Drug delivery systems (DDS) have shown great promise in delivery of drugs and genetic materials or pharmaceuticals and other xenobiotics to their site of action within an organism and eliminate the side effect and enhance the therapeutic effects of the drugs at exact delivery position
RNA interference was first identified as a defence mechanism against the invasion of foreign genes in the nematode Caenorhabditis elegans and had subsequently been discovered in diverse eukaryotes such as fungi, insects, plants, and vertebrates
Researchers demonstrated that synthetic Small interfering RNA (siRNA) were able to induce RNAi in mammalian cells
Summary
Drug delivery systems (DDS) have shown great promise in delivery of drugs and genetic materials or pharmaceuticals and other xenobiotics to their site of action within an organism and eliminate the side effect and enhance the therapeutic effects of the drugs at exact delivery position. Small interfering RNAs (siRNA) has been used extensively in blocking various genes and is presently being evaluated as a therapeutic for cancer and viral disease. Researchers demonstrated that synthetic siRNAs were able to induce RNAi in mammalian cells.
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