Sinus histiocytosis with massive lymphadenopathy—Properties of cultured histiocytes

Abstract

This paper describes the properties of cultured histiocytes derived from lymph node material of a patient with sinus histiocytosis. Before culture the cytoplasm of the histiocytes contained numerous leucocytes, residual bodies and large spherical membrane-bound inclusions of moderate electron density. After prolonged culture, these features disappeared from the cytoplasm. However, when buffy coat cells from a normal individual were brought in contact with the cultured histiocytes, they were phagocytozed and the residual bodies and the large spherical electron dense bodies then reappeared in the cytoplasm of the histiocytes.