Abstract
Eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.
Highlights
Genus Sinularia is a soft coral belonging to the phylum, Cnidaria, class Alcyonaria and familyAlcyoniidae
The 1H NMR spectrum indicated the presence of one methoxyl singlet, two methyl singlets and one terminal methyl triplet (Table 2)
Comparison with 5 showed almost the same NMR spectroscopic data as 3, except for the presence of a methoxyl carbon at δC 54.7 and a oxygenated methine at δC 86.9, while a methylene signal appeared at δC 37.0 in 3 (Table 2)
Summary
Genus Sinularia is a soft coral belonging to the phylum, Cnidaria, class Alcyonaria and family. It constitutes a dominant portion of the biomass in the tropical reef environment [1]. During the course of our investigation on the bioactive chemical constituents from the soft coral, eight new compounds, sinulolides A–H (1–8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10) (Figure 1), were isolated from. Sinularia sp., collected off the Dongluo Island, Sanya, in July, 2009, at a depth of 10 m. The bioactivities of these compounds were determined through bioactivity tests using high-throughput screening (HTS). We describe the isolation, structure elucidation and bioactivities of these compounds
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