Abstract
The Synthesis of acetophenone derivative from 1-(4-acetoxyphenyl- 3-methoxy)-2-propanyl formate through Fries Rearrangement in order to produce ortho hidroxy acetophenone derivative as starting material of Flavanoid compound has been done. The reaction of 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate was done by heating at 120 °C for 3 hours under AlCl3, dichloromethane as the catalyst and solvent, respectively. The structure of the compound was identified using Infra Red spectrometry (IR) dan GC-MS. Fries rearrangement of 1-(4-acetoxyphenil-3- methoxy)-2-propanyl formate produce 1-(2-hyidroxy-3-methoxy-5-propenyl)- acetophenone and 1-(2-hyidroxy-3-methoxy-5-propanyl)-acetophenone as side product with product rendemen were 43.26% and 9.48%, respectively.
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