Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum

Abstract

An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H2O2/Aβ25–35 induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC50 of 32.6μM.