Sinonasal Schwannoma: Retrospective Review of Cases from 1997-2016 at A Tertiary Referral Centre

Abstract

Sinonasal schwannomas (SNS) are benign neoplasms of peripheral nerve sheaths within sinonasal cavities and little is known about them. We aim to expand current literature by analysing all cases of SNS at the National University of Malaysia Medical Centre (UKMMC). There were five females and one male in this study. Mean age was 52.3±2.1 years (range 42-75). The mean tumour size was 3.6cm±0.1 (range 1.50-5.90cm). Tumours originated from outside the sinonasal cavities (n=4) and inside (n=2). Extension was present in five patients. The sinonasal cavity most frequently involved is the maxillary sinus (n=3). Clinical presentation corresponded to site of involvement with facial numbness being the most common presentation. All histopathologically diagnosed cases showed regions of Antoni A, Antoni B, Verocay Bodies and immunoreactivity with S100 protein. Four patients underwent Functional Endoscopic Sinus Surgery (FESS). The presentation of SNS corresponds to their site. Site of involvement is more informative than the site of origin. Endoscopy, CT scans and MRIs are helpful in facilitating an accurate diagnosis. SNS show specific histopathological findings and its main treatment is FESS.