Sinonasal and Asthma Outcomes after Aspirin Desensitization following Endoscopic Sinus Surgery in Aspirin Exacerbated Respiratory Disease

Abstract

Aspirin exacerbated respiratory disease (AERD) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. AERD has been known to be the most severe form of chronic rhinosinusitis, marked by a larger polyp burden and higher rates of recurrence after endoscopic sinus surgery (ESS). Although ESS improves sinonasal symptoms and asthma severity score, it does not address the underlying abnormal metabolism of arachidonic acid. Herein, we describe two cases of AERD presented as recurrent nasal polyposis after ESS, which was successfully treated with aspirin desensitization following ESS.