Abstract
Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.
Highlights
Sinomenii Caulis is the dried cane of Sinomenium acutum (Thunb.) Rehd. et Wils. or Sinomenium acutum (Thunb.) Rehd.et Wils. var. cinereum Rehd. et Wils. [1]
When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was higher than 95%
Assuming that the volume of the aqueous phase did not change before and after liquid-liquid extraction, the extraction ratio was calculated with Equation (2)
Summary
Sinomenii Caulis is the dried cane of Sinomenium acutum (Thunb.) Rehd. et Wils. or Sinomenium acutum (Thunb.) Rehd.et Wils. var. cinereum Rehd. et Wils. [1]. Sinomenii Caulis is the dried cane of Sinomenium acutum (Thunb.) Rehd. Sinomenine hydrochloride is produced using the processes of percolation, filtration, pH adjustment, liquid-liquid extraction, concentration, crystallization and so on. Pharmaceutical continuous manufacturing refers to the process in which materials continuously enter the pharmaceutical system, and drug products continuously come out of it [4]. It is considered as one of the pharmaceutical emerging technologies [5]. There is no published work on the continuous liquid-liquid extraction process of TCMs. In this work, chloroform was used as the extractant to purify Sinomenii Caulis extract. Centrifugal extractors were applied to realize a continuous liquid-liquid extraction process.
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