Abstract
BackgroundChronic cough is a common complaint which affects a large number of patients worldwide. Increased cough sensitivity is a very important cause of chronic persistent cough. However, there are limited clinical diagnosis and treatment for increased cough sensitivity. Transient receptor potential vanilloid-1 (TRPVl) is a member of the transient receptor potential (TRP) family of channels which is very closely associated with respiratory diseases. However, the mechanism through which TRPV1 that influences downstream events is still poorly understood.ResultsCapsaicin induced increase in cough sensitivity by upregulating the protein level of TRPV1, leading to the secretions of Substance P and neurokinin A which stimulated neurogenic inflammation. However, sinomenine, a component of traditional Chinese medicine, significantly attenuated the capsaicin-induced cough by inhibiting the expression of TRPV1 in guinea pigs. In addition, capsaicin increased the expression of SOX5 which mediated the transcriptional upregulation of TRPV1. However, pretreatment with sinomenine reduced the expression of SOX5.ConclusionThese results indicate that capsaicin induced increase in cough sensitivity by activating neurogenic inflammation, while sinomenine attenuated the increase in cough sensitivity by inhibiting the expressions of SOX5 and TRPV1 in guinea pigs. This finding may provide a novel target for the treatment of aggravated cough sensitivity.
Highlights
Chronic cough is a common complaint which affects a large number of patients worldwide
Sinomenine inhibited the expression of transient receptor potential vanilloid-1 (TRPV1) and secretions of Substance P (SP) and neurokinin A (NKA), and attenuated increased cough sensitivity
To determine the effect of sinomenine on increased cough sensitivity induced by neurogenic inflammation, a guinea pig model of increased cough sensitivity was used
Summary
Chronic cough is a common complaint which affects a large number of patients worldwide. Sinomenine was originally found to be effective in treating rheumatism in Japan since the early 1930s (Yamasaki, 1976). It can function as an immune suppressor since it inhibits lymphocyte proliferation and suppresses the synthesis of B-cell antibodies (immunoglobulin G) in cells and animals (He et al, 2005; Feng et al, 2007). Sinomenine Attenuated Cough Sensitivity a vital role in varied biological processes such as cell proliferation, apoptosis, metastasis, and angiogenesis (Ou et al, 2011; Feng et al, 2019; Zhang et al, 2019). The mechanism through which sinomenine prevents airway inflammation is still poorly understood
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