Abstract
Sinoaortic denervation in rats induced changes in endogenous levels of serotonin (5-HT) and 5-hydroxyindole-acetic acid (5-HIAA) in brain areas. The midbrain showed a sustained increase for 7 days after the operation, while in pons and medulla oblongata a marked rise was only observed during the first the 24 h. No changes were obtained in spinal cord. It is thought that the changes in serotonergic activity described could be related to the neurogenic hypertension induced by sinoaortic denervation.
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