Abstract
Diurnal intraocular pressure (IOP) measurements are recommended in cases of visual field deterioration in glaucoma patients. In this study the rationale of 24h versus 48h IOP measurements was investigated. Mean IOP and maximum IOP values were obtained in 80 patients over a period of 48h. The IOP measurements (Goldmann tonometry) of day 1 and 2 (taken every 4h) were compared. To reduce interindividual and intraindividual differences of measurements the statistical calculation took a tolerance level of ± 2mmHg and ± 1mmHg into account. Maximum IOP measurements were found to differ between 37.5% and 65.0% respectively for right eyes and 28.8% and 47.5% respectively for left eyes depending on the measurement tolerance (±2mmHg or ±1mmHg) between day 1 and day 2. Mean IOP values were found to differ by 25% and 51.3% respectively for right eyes and 26.3% and 46.3% respectively for left eyes (± 2 or ± 1mmHg in) between day 1 and day 2. A time-related clustering of extreme deviations could not be found but the maximum values from all patients were found to be roughly equally distributed over daytime and nighttime hours. Both maximum IOP and mean IOP measurements were found to differ by at least ± 2 or ± 1mmHg between day 1 and 2 at a significant percentage and the maximum values did not peak at a predictable time point during the 48h. Therefore, 48h IOP measurements appear to be more reliable than 24h measurements.
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