Abstract
The cell-damaging photochemistry of hematoporphyrin derivative (HPD) has been investigated using isolated erythrocyte membranes as a test system. Irradiation of membranes in the presence of the tumor-localizing fraction of HPD resulted in formation of singlet molecular oxygen ( 1O 2) as measured by the phosphorescence at 1268 nm. The authentic product of 1O 2 attack on cholesterol, 3β-hydroxy-5α-cholest-6-ene-5-hydroperoxide, was identified in this system. Relatively insignificant amounts of free radicalderived hydroperoxides were detected. These results suggest that 1O 2 plays a major role in the HPD-sensitized photokilling of tumor cells in vivo.
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