Abstract
The generation of singlet oxygen (SO), primarily by using a combination of light and photosensitizers in the presence of a dissolved gas, finds applications in both chemistry and medicine. The efficiency of its formation can be enhanced by immobilization of the photosensitizers. In this work, we have explored the covalent functionalization in suspension of hexahedral slab-like polysilicon microparticles ( [Formula: see text]P, with a largest dimension of three microns) with a model photosensitizer, 5-(4-isothiocyanatophenyl)-10,15,20-(triphenyl)porphyrin (ITC-P), and evaluated the singlet oxygen generation of this photosensitizer in solution and after immobilization (ITC-P-[Formula: see text]P) in suspension. The SO-detection experiment on the functionalized microparticles was performed using a hydrogel as the matrix supporting the microparticles (to avoid their settling), and revealed that ITC-P-[Formula: see text]Pin suspension is capable of generating SO more efficiently than free ITC-P in solution.
Highlights
Hybrid materials obtained by the combination of micro- and nanotechnology are considered as extremely relevant to science and technology, in particular for applications in biomedical science, catalysis and waste treatment [1,2,3]
The achievement ofchemical functionality relies on the use of different materials as substrates for the formation of self-assembled monolayers (SAMs) [12], gold [3,13] and silicon [9,14] being the most widely used and studied, because of the ease of using thiol and silane connectors, respectively, to be attached onto the corresponding surfaces to form well-organized SAMs and because the substrates are biocompatible and chemically stable materials
We have explored the phototoxicity of photosensitiserfunctionalized iron oxide [37] and gold nanoparticles [38,39,40] as potential carriers of use in photodynamic therapy (PDT) [41]
Summary
Hybrid materials obtained by the combination of micro- and nanotechnology are considered as extremely relevant to science and technology, in particular for applications in biomedical science, catalysis and waste treatment [1,2,3]. Some of the most important challenges concerning SAMs usage are to select a methodology to obtain a well-organized SAM, to find a simple method to characterize and quantify the monolayer [15] and, more significantly, to be able to correlate chemical synthesis, characterization and function of the new material. Besides the SAMs have been synthetized to produce biosensors, super hydrophilic/hydrophobic surfaces, charged surfaces or to endow substrates of several properties [16,17]. It provides great potential in surface design of monolayers for bioactive coating for biomedical devices such as drug delivery and sensor systems [18,19,20,21]
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