Abstract
This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06–2.59; recessive, OR: 1.64, 95% CI: 1.06–2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03–5.66; recessive, OR: 2.80, 95 % CI: 1.21–6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01–1.65). Rs2978974 influenced the breast cancer risk among postmenopausal women in heterozygote model (OR: 1.47, 95% CI: 1.05–2.07). When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status (homozygote model, OR: 1.98, 95% CI: 1.08–3.63; recessive, OR: 1.87, 95% CI: 1.04–3.37), and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01–4.31). Further haplotype analysis suggested that Trs2294008 Ars2976392 Grs2978974 haplotype enhances breast cancer risk (OR:1.52, 95%CI:1.23-1.89, P<0.001). Therefore, among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively. Moreover, Trs2294008 Ars2976392 Grs2978974 haplotype was associated with significantly increased risk of breast cancer.
Highlights
Breast cancer is the most common cancer and the principal cause of cancer-related deaths among Chinese women [1], accounted for 248,620 new cases and 60,473 cancer-related deaths during 2011 [2]
This study explored the associations between common PSCA single-nucleotide polymorphisms and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women)
When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status, and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01– 4.31)
Summary
Breast cancer is the most common cancer and the principal cause of cancer-related deaths among Chinese women [1], accounted for 248,620 new cases and 60,473 cancer-related deaths during 2011 [2] It is a multifactorial disease influenced by complex interactions between genetic, environmental, and lifestyle factors [3]. A single study with small sample sizes (456 patients and 461controls) revealed that the PSCA SNPs were associated with breast cancer susceptibility among Korean women [9]. The present study aimed to comprehensively examine the potential association of three SNPs (rs2294008 C>T, rs2978974 G>A, and rs2976392 G>A) in PSCA with the risk of breast cancer among a population of Chinese women
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