Year-end Sale % OFF 
Abstract
Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the CD36 gene. Obese (n 50; BMI 34⋅97 (sd 4⋅02) kg/m2) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight (n 50; BMI 22⋅16 (sd 1⋅81) kg/m2) participants (1⋅20 (sd 3⋅23) mmol/l; P = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to CD36 genotype.
Highlights
Obese subjects have shown a preference for dietary lipids
Keeping in mind the aforementioned observations on fat taste alteration in obesity and the implications of CD36, we investigated the role of the CD36 rs1761667 SNP in the orogustatory perception of oleic acid (OA) in obese and normalweight Moroccan subjects
We could not presume this fact in our participants since we had not studied their dietary intake, but we suppose the existence of an association between a high-fat diet and increased OA detection thresholds as our results showed a link between body composition and OA acid taste sensitivity; as already mentioned by other studies[10,11]
Summary
Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Recent studies have supported the existence of a high preference for dietary lipids in obese subjects compared with lean participants[9,10,11,12]. Keeping in mind the aforementioned observations on fat taste alteration in obesity and the implications of CD36, we investigated the role of the CD36 rs1761667 SNP in the orogustatory perception of oleic acid (OA) in obese and normalweight Moroccan subjects. This would be the first study on a Moroccan population
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
