Abstract
We prepare disposable single-walled carbon nanotube network electrodes for the detection of the potent opioid fentanyl, currently a leading cause for opioid overdose deaths in the USA. We show repe...
Highlights
Fentanyl (N-phenyl-N-[1-(2-phenylethyl)piperidinyl]propanamide) is a highly potent synthetic μ-opioid receptor agonist, an analgesic widely used to treat acute and chronic severe pain
We have previously shown that we can synthesize highly pure single-walled carbon nanotube (SWCNT) networks with low defect density that are hydrophobic in nature.[21−23] The hydrophobicity of SWCNT networks and lipophilicity of fentanyl are expected to enhance the adsorption due to the large entropic driving force
Fresh stock solutions were prepared every measurement day by diluting in pH 7.4 phosphate buffered saline (PBS) solution to achieve a concentration of 30 μM fentanyl
Summary
Fentanyl (N-phenyl-N-[1-(2-phenylethyl)piperidinyl]propanamide) is a highly potent synthetic μ-opioid receptor agonist, an analgesic widely used to treat acute and chronic severe pain. Because of its high potency, 50−100 times higher than that of morphine,[3] the therapeutic plasma concentrations of fentanyl are extremely low.[1] Even in cases of fatal acute poisoning, concentrations remain in the range of 100 nM.[4−6] Currently, determination of fentanyl requires specialized and highly sensitive equipment such as gas chromatography−mass spectrometry (GC-MS) or liquid chromatography−mass spectrometry (LC-MS). These methods are, usually laborious, time-consuming, expensive, and confined to specialized laboratories and are poorly suited for point-of-care testing. We demonstrate spontaneous enrichment and highly sensitive detection of fentanyl
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
