Single versus double volume exchange transfusion in jaundiced newborn infants

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary To compare the effectiveness of single volume exchange transfusion (SVET) with that of double volume exchange transfusion (DVET) in producing survival without disability at two years or longer in newborns with severe jaundice. To compare the effectiveness of single and double volume exchange transfusion in reduction of bilirubin levels. To compare the frequency of adverse events related to single and double volume exchange transfusions. Secondary Subgroups representing the different etiologies for hyperbilirubinaemia Rhesus haemolytic disease Haemolytic disease other than rhesus haemolytic disease Newborn infants without haemolysis Preterm babies (=< 28 weeks, 29 ‐ 32 weeks, 33‐36 weeks) Serum bilirubin level ( =<200 micromoles/L, 201‐399 micromoles/L, > 399 micromoles/L) Newborns infants with established kernicterus Newborn infants in whom metalloporphyrins have been used