Single-trial coupling of EEG and fMRI during recognition reveals the generators of ERP old/new effects

Abstract

Event Abstract Back to Event Single-trial coupling of EEG and fMRI during recognition reveals the generators of ERP old/new effects Michael Hoppstädter1, 2*, Christian Bäuchl1, 2, Carsten Diener1, 2, Herta Flor1, 2 and Patric Meyer1, 2 1 Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Department of Cognitive and Clinical Neuroscience, Germany 2 Bernstein Center for Computational Neuroscience Heidelberg/Mannheim, Germany Recognition means the ability to decide if information was encountered previously. This can be featured with additional details from the encoding episode or not. Various behavioural, electrophysiological and imaging studies have pinpointed that two differential processes are involved in recognition memory, namely recollection and familiarity. Recollection describes the conscious retrieval of contextual information about a specific episode, while familiarity means only a feeling of knowing without additional contextual details. These processes may be differentiated electrophysiologically by means of event-related potentials (ERPs). In contrast to correctly rejected new items, items correctly classified as old yield a more positive ERP deflection which is termed old/new effect. One earlier frontally localized old/new effect emerging from about 300 ms after stimulus onset relates to familiarity processing whereas a functionally distinct later parietal effect is associated with recollection. Functional magnetic resonance imaging (fMRI) has revealed that within the medial temporal lobe, extrahippocampal cortical areas and the hippocampus proper support independently recognition based on familiarity or recollection, respectively. In order to examine the relation between hemodynamic changes and the modulation of ERP old/new effects during memory retrieval, we conducted a simultaneous EEG-fMRI study in 16 young healthy volunteers. Standard ERP analyses revealed an early mid-frontal and a later parietal old/new effect, presumably associated to the differential use of familiarity and recollection during recognition. FMRI old/new contrasts showed activity modulation in the hippocampus as well as in the precuneus, the retrosplenial cortex and the medial frontal gyrus. An EEG-informed fMRI analysis was performed to relate single-trial ERP amplitudes to hemodynamic signal changes, thus accounting for trial-to-trial fluctuations. By orthogonalisation to the standard stimulus-coding predictors the variance explained by the trial-to-trial modulation of the old/new effects was isolated. The results complement rare data from intracranial ERP recordings and patient studies. The results from this multimodal fusion analysis will be embedded into biophysically and anatomically detailed models of hippocampal-prefrontal interaction which will in turn generate predictors for the outcome of future imaging studies. Acknowledgements This study was supported by the Bundesministerium für Bildung und Forschung. Keywords: EEG-fMRI, Long-term memory, medial temporal lobe, retrieval Conference: Bernstein Conference 2012, Munich, Germany, 12 Sep - 14 Sep, 2012. Presentation Type: Poster Topic: Learning, plasticity, memory Citation: Hoppstädter M, Bäuchl C, Diener C, Flor H and Meyer P (2012). Single-trial coupling of EEG and fMRI during recognition reveals the generators of ERP old/new effects. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 10.3389/conf.fncom.2012.55.00122 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 May 2012; Published Online: 12 Sep 2012. * Correspondence: Mr. Michael Hoppstädter, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Department of Cognitive and Clinical Neuroscience, Mannheim, Germany, michael.hoppstaedter@zi-mannheim.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Michael Hoppstädter Christian Bäuchl Carsten Diener Herta Flor Patric Meyer Google Michael Hoppstädter Christian Bäuchl Carsten Diener Herta Flor Patric Meyer Google Scholar Michael Hoppstädter Christian Bäuchl Carsten Diener Herta Flor Patric Meyer PubMed Michael Hoppstädter Christian Bäuchl Carsten Diener Herta Flor Patric Meyer Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.