Abstract
Responses to single tones and two-tone inhibition (TTI) above CF were determined in untreated Mongolian gerbils and after kanamycin or impulse-noise treatment. Kanamycin produced maximum hair-cell damage in the basal cochlear turn, the noise, in the mid-cochlear region and sometimes in the base. Fibers associated with 100% loss of outer hair cells (OHC) in the basal turn showed elevated CF thresholds, reduced slopes of tuning curves, no TTI, steep rate-intensity curves above CF, and excitation during basilar-membrane displacement towards scala vestibuli. In the presence of 50–95% OHC loss restricted to 2–4 mm of the midcochlear region, corresponding fibers exhibited less homogeneous characteristics. CF thresholds corresponding to the basal boundary of the lesion were nearly normal and increased toward and beyond the apical boundary. The tuning curves tended to be somewhat broadened and TTI, though reduced, was still present in fibers with elevated CF thresholds. Fiber excitation usually occurred during basilar-membrane displacement towards scala vestibuli. Some fibers from both treated groups showed increased sensitivity below CF despite elevated CF thresholds. Tuning curves associated with no TTI had high-frequency slopes between 70–200 dB/oct.
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