Single stranded DNA-binding proteins: Current Opinion in Structural Biology 1992, 2:124…-130

Abstract

The past year has seen steady progress in our understanding of single stranded DNA-binding proteins and their interaction with DNA, most notably of the gene 5 proteins of bacteriophages fd and Pf, the gene 32 protein of bacteriophage T4 and the Escherichia coli SSB protein. A brief survey is given of recently identified single stranded DNA-binding proteins from both prokaryotic and eukaryotic sources, a number of which show pronounced sequence specificity. The crystal structure of the E. coli recA protein, which binds to both single-stranded and duplex DNA, has very recently been reported, and is briefly discussed.