Single-stage synthesis of 3-hydroxy- and 3-alkoxy- 5-arylimidazolidine-2,4-diones by reaction of arylglyoxal hydrates with N -hydroxy- and N -alkoxyureas

Abstract

Arylglyoxal hydrates interact with N -alkoxyureas and N -hydroxyurea in acetic acid with selective formation of 3-alkoxy-5-arylimidazolidine-2,4-diones and 5-aryl-3-hydroxyimidazolidine-2,4-diones, respectively. The structures of 3-methoxy-5-phenylimidazolidine-2,4-dione, 3-ethoxy-5-phenylimidazolidine-2,4-dione, and 3-butoxy-5-(4-chlorophenyl)imidazolidine-2,4-dione were studied by X-ray structural analysis. How to Cite Shtamburg, V. G.; Shtamburg, V. V.; Anishchenko, A. A.; Zubatyuk, R. I.; Mazepa, A. V.; Klotz, E. A.; Kravchenko, S. V.; Kostyanovsky, R. G. Chem. Heterocycl. Compd. 201 5 , 51 , 553. [ Khim. Geterotsikl. Soedin. 2015 , 51 , 553.] For this article in the English edition see DOI 10.1007/s10593-015-1735-0