Abstract
ObjectiveThis study aims to compare the sensitivity of dual phase (non-contrast and arterial) versus single phase (arterial) CT for detection of hyper-functioning parathyroid glands in patients with primary hyperparathyroidism.MethodsThe CT scans of thirty-two patients who have biochemical evidence of primary hyperparathyroidism, pathologically proven parathyroid adenomas, and pre-operative multiphase parathyroid imaging were evaluated retrospectively in order to compare the adequacy of single phase vs. dual phase CT scans for the detection of parathyroid adenomas.ResultsThe parathyroid adenomas were localized in 83% of cases on single arterial phase CT and 80% of cases on dual phase CT. The specificity for localization of parathyroid tumor was 96% for single phase CT and 97% for dual phase CT. The results were not significantly different (p = 0.695). These results are similar to those found in the literature for multiphase CT of 55–94%.ConclusionsOur study supports the use of a single arterial phase CT for the detection of hyperfunctioning parathyroid adenomas. Advances in knowledge: a single arterial phase CT has similar sensitivity for localizing parathyroid adenomas as dual phase CT and significantly reduces radiation dose to the patient.
Highlights
Primary hyperparathyroidism occurs in 0.2% to 0.5% of the general population with approximately 100,000 new reported cases per year in the United States and estimated annual incidence of 27.7 per 100 person years (Liebert, 1991; Wermers et al, 1997)
75–85% of primary hyperparathyroidism is caused by hormone overproduction by a single hyperfunctioning gland (Fraser, 2009; Ghandur-Mnaymneh & Kimura, 1984)
The preoperative serum calcium ranged from 9.6–13.2 mg/dL and serum intact parathyroid hormone ranged from 64–789 mg/dL
Summary
Primary hyperparathyroidism occurs in 0.2% to 0.5% of the general population with approximately 100,000 new reported cases per year in the United States and estimated annual incidence of 27.7 per 100 person years (Liebert, 1991; Wermers et al, 1997). 75–85% of primary hyperparathyroidism is caused by hormone overproduction by a single hyperfunctioning gland (Fraser, 2009; Ghandur-Mnaymneh & Kimura, 1984). How to cite this article Morón et al (2017), Single phase computed tomography is equivalent to dual phase method for localizing hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: a retrospective review. Invasive technique (MIT) is associated with decreased morbidity relative to four-gland exploration. This technique may be performed under local anesthesia which can be performed in candidates who may not be sutitable for general anesthesia and can be used to prevent the need for overnight hospitalization (Suliburk & Perrier, 2007)
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