Single nucleotide polymorphisms of the interleukin-1 superfamily members: аssociation with viral hepatitis B and C

N V Vlasenko,S N Kuzin,N S Churilova,V V Klushkina,T A Semenenko,Ya V Panasyuk,E N Kudryavtseva,D V Dubodelov,N G Akimkin

doi:10.36233/0372-9311-121

Abstract

The review provides information on single nucleotide polymorphisms (SNPs) in genes encoding some interleukins belonging to the interleukin-1 (IL-1) superfamily and on their association with different infectious and non-infectious human diseases. It also briefs on the history of SNP discovery and the progress in the related scientific studies till the present time. It gives an insight into some mechanisms of interaction between infectious agents and the human immune system, involving SNPs in some cytokines of the IL-1 superfamily. The review provides data on relationships of SNPs in genes encoding other factors of the immune system, which are associated with the specific characteristics of natural history of chronic hepatitis B and C. It explores the significance of assessment of the SNP-proportion in proinflammatory cytokines and their antagonists of the IL-1 superfamily among the healthy population as well as the ratio of individual SNPs in specific groups of patients as a monitoring parameter for epidemiological surveillance of infectious diseases.

Highlights

The review provides information on single nucleotide polymorphisms (SNPs) in genes encoding some interleukins belonging to the interleukin-1 (IL-1) superfamily and on their association with different infectious and non-infectious human diseases
It briefs on the history of SNP discovery and the progress in the related scientific studies till the present time
It gives an insight into some mechanisms of interaction between infectious agents and the human immune system, involving SNPs in some cytokines of the IL-1 superfamily

Summary

Группа сравнения Сomparison group

Определили, что у пациентов с ХГВ генотип АА rs1800896 (G→A) IL-10 (Gene ID: 3586) может рассматриваться как риск-фактор формирования ЦП и ПРП по сравнению с аллелем GG [43]. Польские исследователи обнаружили повышенный риск возникновения ЦП у пациентов с ХГВ при гаплотипе GCCT 1082G/819C/592C/1353T гена IL10 (Gene ID 3586) [44]. Китайские исследователи выявили связь rs4986790 (A→G,T) гена HLA-DPB1 (Gene ID: 3115) с элиминацией HBsAg у пациентов с ХГВ [57]. Связь Т-аллеля rs4986790 (A→G,T) гена HLA-DPB1 (Gene ID: 3115) с повышенным риском хронизации при заражении ВГС выявили при обследовании когорты пациентов в Тунисе [56]. SNP, связанные с достижением устойчивого вирусологического ответа, спонтанного клиренса и высоким риском хронизации у пациентов с ХГВ и ХГС Table 3. Simple nucleotide polymorphisms associated with achieving a sustained virological response, spontaneous clearance, and high risk of chronicity in patients with HBV and HCV infections

CC genotype implies higher probability of spontaneous clearance

Рatients with HCV

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