Abstract
Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype Ars2188972Trs2188971Ars8103163Ars7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.
Highlights
In the worldwide, there are approximately 240 million individuals who carried chronic hepatitis B virus (HBV), it remains a very serious health problem. [1, 2]
We found there existed a correlation between three loci
Our comprehensive analysis of ZNF208 SNPs found that genotypes and haplotypes associate with increasing Hepatitis B virus (HBV) risk
Summary
There are approximately 240 million individuals who carried chronic hepatitis B virus (HBV), it remains a very serious health problem. [1, 2]. Some research studies have extensively investigated the relationship between candidate genes and the progression of HBV infection, including human leukocyte antigen system, cytokines, and killer cell immunoglobulin-like receptors [6,7,8,9]. The relationship between HBV infection and other host genetic diversities need further study. Persistent viral infection, HBV occurrence are influenced by immunological and host genetic factors [10,11,12], all of them are involved in host and virus interaction. In the investigation of disease pathology, researching the relationship between the host immune responses and gene polymorphisms may lead to new insights into HBV infection and the host responses. The future studies in different genes and their polymorphisms should gather useful information for better understanding and characterizing in HBV infection susceptibility
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