Single nucleotide polymorphisms in ORMDL3 gene impact on childhood asthma

Abstract

Objective To examine the single nucleotide polymorphisms in ORMDL3 gene impact on childhood asthma in Guangdong Chinese population. Methods A multicenter, large sample, prospective case-control study was conducted.A total of 598 cases of Guangdong cadastral children (300 cases in asthmatic group and 298 cases in control group)were selected.Using univariate Logistic regression analysis was adopted to analyze the association between ORMDL3 gene SNP rs12603332 CC and the risk factors related to age, gender, family history, atopic history of physique, respiratory virus infection, suction sensitization, and food sensitization.Multifactor Logistic regression analysis was selected to analyze the interactive effect between ORMDL3 gene and the risk factors for childhood asthma. Results ORMDL3 gene SNP rs12603332 CC genotype was significantly associated with family history(P=0.007, OR=1.845, 95%CI 1.178-2.889) and respiratory virus infection(P=0.007, OR=1.976, 95%CI 1.206-3.235). ORMDL3 gene SNP rs12603332 CC genotype, CT genotype and TT genotype had interactive effect with family history[OR=22.644(95%CI 9.390-54.606), OR=33.500(95%CI 7.839-143.157), and OR=11.167(95%CI 1.319-94.559)]. ORMDL3 gene SNP rs12603332 CC genotype, CT genotype and TT genotype had interactive effect with respiratory virus infection[OR=32.476(95%CI 9.875-106.805), OR=12.667(95%CI 3.699-43.375), and OR=7.917(95%CI 0.909-68.945)]. Conclusions ORMDL3 gene SNP rs12603332 CC genotype indicates a high frequency in asthmatic children.The children who have ORMDL3 gene SNP rs12603332 CC genotype are easily attacked by respiratory virus.Compared with other asthma risk factors, SNP rs12603332 and family history of asthma or SNP rs12603332 and respiratory virus infection are more likely to have childhood asthma in Guangdong population. Key words: ORMDL3 gene; Polymorphisms; Childhood asthma; Risk factor; Interaction