Abstract
Gastric cancer is one of the leading worldwide cancers formed in the lining of the stomach, and is the most prevalent cancer in northern Iran. Recent interventions for the early diagnosis of gastric cancer are based on genetic susceptibility parameters and the interactions between genes and the environment. Accordingly, this narrative review was designed to summarize the genetic markers involved in Iranian patients with gastric cancer, classified by cellular function. There was a significant relationship between single nucleotide polymorphisms (SNPs) in rs1051208 C allele (RAF1), rs531564 (pri-miR-124-1), rs1053023 (STAT3), rs8193 C allele (CD44), rs3130932G allele (OCT4), rs283821943, rs2032586 (ABCB1), codons 72,248 (p53), -137 G/C (IL-18), Pro12Ala (PPARγ), rs1053023 (STAT3), rs4647603 (caspase 3), -712C>T (caspase 9), -1263 A> (caspase 9) and gastric cancer. Increased risk was observed in C677T (MTHFR). Finally, decreased risk of gastric cancer was explored in -938 C>A (bcl2). Asp299Gly (TLR-4), rs1028181-513T/C (IL-19) Pro12Ala (PPARγ) may play a crucial role in susceptibility of Helicobacter pylori and gastric pathogenesis. According to the findings, the genetic polymorphisms in the immune-associated genes were related to the gastric cancer among the Iranian patients. Therefore, further large-scale functional investigations are needed to draw definite conclusions.
Highlights
Cancer is one of the leading causes of death around the world
Known as stomach cancer, is one of the most prevalent cancers diagnosed in advanced stages due to poor prognosis [1]
The purpose of this article was to review the single nucleotide polymorphisms (SNPs) studied in gastric cancer in Iran
Summary
Cancer is one of the leading causes of death around the world. Most patients have a low five-year survival rate, even after surgery, and die due to inefficiency of conventional therapies. The gastric cancer is the second leading cause of cancer deaths worldwide. Previous studies have shown that the fiveyear survival rate in Iran has increased by 5% over the past few years, but is still lower than in countries such as China, the United States, Switzerland, France and Japan. About 798 000 patients are diagnosed with gastric cancer each year, with 628 000 people dying from the disease. In East Asian countries, such as China, mortality due to gastric cancer has been ranked first among all other cancers, and this trend has grown rapidly over the past two decades [2]. The cancer incidence is dramatically affected by various factors, such as bacterial infection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
