Single-nucleotide polymorphism microarray testing (SNP) of paraffin-embedded products of conception (PPOC) as first-line assessment for recurrent pregnancy loss (RPL)

Abstract

Previous studies recommend cytogenetic analysis of fresh POC at the time of a second pregnancy loss. When it is not performed or fails to yield a result, ASRM recommends a RPL workup (parental karyotypes, antiphospholipid antibodies (APA), TSH, Prolactin and uterine cavity evaluation). New SNP technology can determine karyotype from PPOC, with the added ability to exclude maternal cell contamination (MCC). This study investigated whether PPOC testing is a suitable alternative to the ASRM RPL workup for the initial evaluation of RPL without prior cytogenetic data.