Abstract
Nanopore is an emerging technique, during the past two decades, has been explore to analysis the information about the identity, concentration, structure, and dynamics of the target molecules. However, the readout signal is mainly related on the tiny changes of ionic current as single molecules pass through the nanopore. Here, we develop the ultra-low current analyzer and combine plasmonic resonance scattering spectroscopy with nanopore technique, which could acquire the optical-electrical dual signals as a molecule pass though the nanopore. It provides more unique information of single biomolecule, which have a significant potential in life science. By virtue of this integrated strategy, we have realize single nucleotide discrimination, and even for the detecting the substituent difference in a molecule, such as DNA cytosine methylation.1. Yi-Tao Long, Rui Gao, Chan Cao, Yi-Lun Ying, Da-Wei Li. CN203572764U[P].2. Gang Logan Liu, Yi-Tao Long, Yeonho Choi, Taewook Kang & Luke P Lee, Nat. Methods, 2007, 4(12), 1015-1017.
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