Abstract
Background: Asthma is a complex and chronic inflammatory airway disease. Asthma’s etiology is unknown; however, genetic and environmental factors could affect disease susceptibility. We designed a case-control study aimed to evaluate the role of single-nucleotide polymorphisms (SNP), and copy-number variants (CNV) in the IL4 and IL13 genes in asthma susceptibility and their participation in plasma cytokine levels depending on genotypes Methods: We include 486 subjects, divided into asthma patients (AP, n = 141) and clinically healthy subjects (CHS, n = 345). We genotyped three SNP, two in the IL4 and two in the IL13 gene; also, two CNVs in IL4. The IL-4, IL-13 and IgE plasma levels were quantified. Results: Biomass-burning smoke exposure was higher in the AP group compared to CHS (47.5% vs. 20.9%; p < 0.01, OR = 3.4). No statistical differences were found in the genetic association analysis. In both CNV, we only found the common allele. For the analysis of IL-4, IL-13, and IgE measures stratified by genotypes, no significant association or correlation was found. Conclusion: In the Mexican-mestizo population, SNPs neither CNVs in IL4 nor IL13 are associated with asthma susceptibility or involved serum cytokine levels. Biomass-burning smoke is a risk factor in asthma susceptibility.
Highlights
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, causing recurrent dyspnea, cough, and wheezing
We reported a median age of 40 years old; we found a significant difference in men-women proportion, finding a higher proportion of women in the asthma patients (AP) group (67.4%), while in the clinically healthy subjects (CHS) group, men were slightly higher (57.9%)
In the exposure to environmental risk factors, the AP group had a higher percentage of exposed to biomass-burning smoke (BBS) than in the CHS group
Summary
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, causing recurrent dyspnea, cough, and wheezing. These events are generally associated with an extensive and variable obstruction of the lung airflow, often irreversible with or without treatment [1]. Asthma’s etiology is unknown; genetic and environmental factors could affect disease susceptibility. No statistical differences were found in the genetic association analysis In both CNV, we only found the common allele. Conclusion: In the Mexican-mestizo population, SNPs neither CNVs in IL4 nor IL13 are associated with asthma susceptibility or involved serum cytokine levels. Biomass-burning smoke is a risk factor in asthma susceptibility
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