Abstract
P-glycoprotein (Pgp) is an ATP-binding cassette transporter which effluxes foreign bodies out of a cell. It non-selectively binds a variety of oncology drugs and is overexpressed in cancer cells, making it a leading cause of multi-drug resistance. Understanding Pgp’s mechanism of action is a critical research effort. Single-molecule atomic force microscopy (AFM) is a technique that directly visualizes membrane-external protrusions of proteins embedded in native lipid environments at physiologically relevant temperatures and ionic strength.
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