Abstract
Single-molecule masspic analysis is able to gain the mass information of a single molecule through nanopore technique. Moreover, a special conjugation of DNA hairpin structure to the poly(ethylene glycol) molecule is designed to enhance the temporal resolution of low molecular weight poly(ethylene glycol) in nanopore studies. With the merit of this design, the detection of an individual PEG with molecular weight as low as 140 Da is achieved at the single-molecule level in solution, which provides a novel strategy for characterization of an individual small molecule within a nanopore.
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