Abstract
We report pulsed interleaved single pair FRET (spFRET) measurements of freely diffusing reconstituted cardiac myofilaments. Under saturating Ca2+ conditions, the measurements reveal a population of unactivated troponin. We suggest that this population of unactivated troponin comprises a form of cardiac reserve that is regulated by signaling pathways that target the myofilament. The results are interpreted in terms of a coarse-grained free energy landscape model of myofilament activation.
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