Abstract
The photo-regulated interactions between an RNA aptamer and photochromic spiropyran were investigated at a single-molecule level via an α-hemolysin nanopore. Upon irradiation of alternating UV/visible light, the translocation process of the RNA aptamer could be optically tuned on account of its different binding affinity with two photoisomers, spiropyran and merocyanine. This provides a general analytic model for understanding the mechanism of a photo-regulated biomolecule conformational change at a single-molecule level.
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