Abstract
A single maxillary central incisor may occur as an isolated dental finding. However, it has also been reported to occur in association with autosomal dominant holoprosencephaly, in association with growth retardation with or without growth hormone deficiency and occasionally in association with other mid-line developmental defects. Holoprosencephaly and pituitary dysfunction are two specific examples of mid-line defects and this report emphasises that other mid-line defects may be associated with a single maxillary central incisor. We recommend that patients with this dental anomaly should be referred for a detailed medical examination.
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