Single low-dose rituximab for the treatment of steroid-resistant nephrotic syndrome with acute kidney injury

Abstract

The efficacy of rituximab for kidney disease, such as frequent relapsing nephrotic syndrome, has been reported recently. Herein, we report a case of a patient with acute kidney injury that was steroid-resistant nephrotic syndrome who responded to a single administration of low-dose rituximab. An 86-year-old Japanese woman with hypertension presented with severe peripheral edema within several days after onset. Due to the patient's age, renal biopsy was not performed, nephrotic syndrome was diagnosed and prednisolone was administered at 40mg/day on the day after admission. However, anuria developed and hemodialysis was inevitably initiated on the 5th hospital day. The renal function did not recover, and the general condition gradually became aggravated. On the 50th hospital day, 100mg rituximab was administered, which led to immediate depletion of CD20-positive cells. The urine volume gradually increased from 2-3weeks after the rituximab administration, and the renal function recovered slightly. After 5weeks, it became possible to wean the patient from dialysis, which had been applied for 3months. Rituximab might be an option for the treatment of acute kidney injury due to steroid-resistant nephrotic syndrome.