Abstract
In the affective disorders, the fact that multifactorial models are consistent with some studies and single locus models are usually rejected does not necessarily rule out single locus inheritance. The power of these methods to detect major loci in complex diseases may be low. Goldin et al.1 found by simulation that a single locus for a disease could not be identified for certain modes of inheritance, especially “quasirecessive” inheritance, where the heterozygote individuals have low, but not zero, penetrance. In addition, if affective disorders are genetically heterogeneous, the detection of single locus genetic mechanisms may require a valid linkage marker or single-gene vulnerability factor.
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