Abstract
We present a nano-optical probe for real-time refractive index measurement of single live cell. The probe was made of a tapered fiber tip coated with 13 nm diameter gold nanoparticles. The evanescent wave near the tip excited localized surface plasmon resonance of gold nanoparticles. By measuring the optical intensity scattered from the nanoparticles, the probe showed an intensity sensitivity up to ∼5400% per refractive index unit. The 3T3 fibroblast cell was tested by inserting the probe into the cytoplasm. Refractive index as measured by the localized plasmonic effect was 1.3506, consistent with the results measured by holographic methods.
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