Abstract
A graphene-based surface plasmon resonance (SPR) prism coupler sensor is proposed for the rapid detection of immunoglobulin G (IgG) antibodies. The feasibility of the proposed sensor is demonstrated by measuring the IgG concentration in phantom mouse and human serum solutions over the range of 0–250 ng/mL. The results show that the circular dichroism and principal fast axis angle of linear birefringence increase in line with increases in IgG concentration over the considered range. Moreover, the proposed device has a resolution of 5–10 ng/mL and a response time of less than three minutes. In general, the sensor provides a promising approach for IgG detection and has significant potential for rapid infectious viral disease testing applications.
Highlights
Infectious viral diseases such as dengue fever virus, typhoid fever, hepatitis B virus, SARS-CoV-2, or coronavirus disease 2019 (COVID-19) have become a major threat to human life in this century
The validity validity of of the the proposed proposed sensor sensor was was demonstrated demonstrated by by measuring the circular dichroism (R) and principal fast axis angle of linear birefringence (LB) (α) of aqueous solutions containing mouse and human immunoglobulin G (IgG) antibodies in concentrations of 0–250 ng/mL
The results showed that both properties increased in line with the increasing IgG concentration
Summary
Infectious viral diseases such as dengue fever virus, typhoid fever, hepatitis B virus, SARS-CoV-2, or coronavirus disease 2019 (COVID-19) have become a major threat to human life in this century. Since its discovery in 2004, many studies have been published on the optical properties of graphene [11,12] and its wide range of applications [13,14], including graphene-based surface plasmon resonance (SPR) sensors with enhanced sensitivity and resolution [15,16]. Wu et al [22] proposed an enhanced graphene-oxide-based SPR sensor for the detection of human IgG antibodies over a range of 0.075–40 μg/mL with a resolution of 5 μg/mL. A new single-layer graphene-based SPR sensor was developed for mouse and human IgG detection based on differential Mueller matrix polarimetry. An SPR prism coupler was employed for creating the total internal reflectance to perform glucose sensing based on polarization absorption This enabled the utilization of the differential Mueller matrix to perform reflectance configuration. The detection time of the proposed technique is approximately 3 min, including data collection
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