Abstract
Because of their small size and inaccessibility, direct electrical measurements of ionic conductances from mammalian brain presynaptic nerve terminals have not been possible. Measurements using voltage-sensitive fluorescent dyes, however, indicate that the membrane potential of a preparation enriched in pinched-off and resealed presynaptic nerve terminals (synaptosomes) depends principally on K+ conductances (1). To measure ionic conductances from the brain directly, synaptosomal ion channels were incorporated into lipid bilayers. We examined single K+channel currents and found four K+-channels that can be distinguished by their single-channel conductances.
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