Abstract
Purpose: Nowadays, intra-articular hyaluronate (IAHA) injection is one of the common treatments to improve the symptoms of knee osteoarthritis (OA). A recent meta-analysis showed that the most effective and safe HA products were those that derive HA from biological fermentation and have a molecular weight ≧3000kDa. Through cross-linked technique, the molecular weight of HA can be amplified to near infinity, and the time HA remains in the knee also can be prolonged, potentially increasing the efficacy and duration of the treatment effects and providing a single-injection choice.
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