Single-Dose Oral Lacosamide in Refractory Simple Partial Status Epilepticus

Abstract

This study aimed to present 2 patients with simple partial refractory status epilepticus (RSE) treated with a single oral lacosamide (LCM) dose and to review the literature on this topic. A retrospective description of 2 patients with simple partial RSE treated with 300 mg of LCM per os (p.o.) and a literature review were done. Both patients responded to single-dose oral LCM treatment with seizure cessation after 30 minutes. This is the first report on successful treatment of simple partial RSE with a single-dose of LCM p.o.. Oral LCM might represent an option for treatment of patients presenting with simple partial RSE.