Abstract
Human Papilloma Virus (HPV) vaccination of the preadolescent (9-14 years) females is the potential solution to eradicate carcinoma cervix. Nonavalent vaccine provides wider coverage than the quadrivalent vaccine. On long-term follow-up, even after single-dose HPV vaccination, the antibody titer remains good. Herd immunity can also be achieved by HPV vaccination. Hence, mass single-dose nonavalent HPV vaccination for sexually naive preadolescent girls can provide almost 100% protections and a cost-effective approach for the developing countries.
Highlights
Cervical cancer is a preventable disease and whole world is focusing on prevention of carcinoma cervix
Hypothesis of single dose Human Papilloma Virus (HPV) vaccination In the multi-centric Indian clinical trial (NCT00923702) quadrivalent HPV vaccine was given and the participants were ended up in 4 groups – 1) 3 dose group: girls vaccinated on days 1, 60 and 180 or later, 2) 2 dose group: girls vaccinated on days 1 and 180 or later, 3) 2 dose group: girls vaccinated on days 1 and 60 by default and 4) Single dose: by default because administration of vaccine was stopped in April 2010 by Govt of India [2]
US National Cancer Institute Costa Rica trial revealed that though the antibody levels after single dose bivalent HPV vaccine was lower than the levels after 3 doses, but it was 9-times higher than levels elicited by natural infection
Summary
Cervical cancer is a preventable disease and whole world is focusing on prevention of carcinoma cervix. HPV vaccination is the key to eradicate carcinoma cervix. Since the end of 2016, only 9-valent HPV vaccine is available in the United States [1].
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