Abstract
Photosensitivity can be used as a model in short-term studies for assessingthe efficacy of new antiepileptic drugs in man. As a quantitative measure of photosensitivity, the photosensitivity range is employed. This is the range between the highest and the lowest flash rate producing a photoparoxysmal response (generalized paroxysmal activity on the EEG). An efficacious new antiepileptic drug should, like all currently available antiepileptic drugs, reduce the photosensitivity range. Single-dose administration of 100–150 mg of loreclezole resulted in a decreased photosensitivity in all patients tested. This effect was attributable to loreclezole as no acute interactions with valproic acidcould be demonstrated. The rapid onset of activity indicates that loreclezole readily passes the blood-brain barrier. The doses applied were very well tolerated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
